Liverpool overcame an early scare and came from a goal down to claim a 3-1 win at Austria's LASK Linz.
Atletico Madrid made sure of at least a third-placed finish in La Liga and secured a berth in the Champions League group stages for next season with a 3-1 win away to struggling Celta Vigo on Wednesday.
The Champions League group stages took on a less predictable look after Thursday's draw, helped by UEFA's decision to tweak the seeding system.
Antoine Griezmann and Samuel Lino scored in each half to give Atletico Madrid a 2-0 win over Lazio on Wednesday that secured them top spot in Champions League Group E, the first time since 2016 that they had reached the knockouts as group winners.
United captain Jesse Lingard fired them ahead in the 10th minute with a fizzing low shot from 20 metres before Dmitri Shomko and a Di'Shon Bernard own goal turned the match on its head shortly after half-time.
Going into the ground, some Israel fans wore both Israeli and French colours. Two wore a t-shirt with Israeli club side Maccabi Tel Aviv's logo on the front and the words "Ni Oubli Ni Pardon" (Never Forgive Never Forget) on the back.
Arsenal are not only hoping to win a first European trophy since 1994, but know their hopes of qualifying for next year's Champions League depend on winning the Europa League in the French city of Lyon next month.
Panathinaikos secured a Champions League qualifying spot by beating PAOK Salonica 2-0 on Sunday to extend their lead in the Super League playoffs to a eight points with two matches left.
News of all that's transpired on and off the football field
Chelsea are in the last chance saloon as far as a trophy goes and Fernando Torres, complete with his 'Mask of Zorro', must continue his recent improvement in swashbuckling style in Thursday's Europa League semi-finals.
A round-up of Wednesday's action in the UEFA Champions League.
Barcelona have reached the semis only once since winning the Champions League in 2014-15.
Rodrigo Palacio snatched an 88th minute win for Inter Milan over Partizan Belgrade in the Europa League on Thursday while Lazio were on the wrong end of some late drama in a 1-1 draw at Panathinaikos.
VAR system would be used in the final qualifying round, the group stage and the knockout stages of next season's Champions League.
Images from UEFA Champions League matches played on Wednesday.
In other ties, Serie A champions Juventus face Europa League winners Atletico Madrid and Barcelona take on Olympique Lyonnais.
West Ham United, reduced to 10 men after defender James Tomkins was sent off in the first half, won 5-3 in a penalty shootout against Maltese Cup winners Birkirkara to scrape into the Europa League third qualifying round on Thursday.
Last-minute starter Adrian Ramos scored a first-half header to give Borussia Dortmund a 1-0 victory over Sporting on Wednesday and earn a spot in the knockout stage of the Champions League with two Group F matches to spare.
Unai Emery's side were heading for a demoralising defeat, three days after losing meekly to Sheffield United in the Premier League, but substitute Pepe's late intervention kept the Gunners top of Group F with a maximum nine points.
Metalist Kharkiv, due to play Schalke 04 in the Champions League play-off round next week, has been kicked out of the competition over a domestic match-fixing case dating back to 2008, the UEFA said on Wednesday. The decision by UEFA's appeals committee came 10 days after Metalist lost an appeal at the Court of Arbitration for Sport.
IMAGES from the Champions League matches played on Tuesday.
IMAGES from the UEFA Champions League matches played on Tuesday
Manchester City's dismal exit from European competition is not an embarrassment and could boost the big-spending club's defence of the Premier League title, according to manager Roberto Mancini.
A round-up of Saturday's action in the UEFA Nations League group stage matches.
Man United out of Europe after 1-0 home loss to Bayern Munich
;You will have setbacks. We beat Arsenal, we beat Liverpool. On Sunday, we had a bad day at the office. City were better, we have to accept that. But we can't accept our unacceptable performance. So thank you for the lesson, Pep and City. We have to understand, we have to do things much better.'
A round-up of Saturday's action the Bundesliga, Ligue 1
Romanians Astra handed West Ham United their first competitive defeat at the London Stadium as Slaven Bilic's team were beaten in the Europa League playoffs on Thursday.
Russia's bid to host the Euro 2028 or the Euro 2032 tournaments have also been declared ineligible, the Switzerland-based governing body said.
Klopp has led Liverpool to back-to-back Champions League finals but is adamant that their impressive recent track record does not make them the title favourites.
Bulgarian police detained 45 fans of Croatian champions Dinamo Zagreb for acts of violence before their team's Europa League match against Bulgarian champions Ludogorets on Thursday.
Manchester United need to win trophy to save season, says Wayne Rooney.
Goals from Henrikh Mkhitaryan, who made a mockery of his two-month exile from the starting lineup with a superb individual effort, and Zlatan Ibrahimovic secured an easy win that banished memories of their earlier group stage struggles.
On a good night for English clubs in the Europa League, Manchester United hammered AZ Alkmaar 4-0, while Wolverhampton Wanderers also thrashed Besiktas 4-0 in Group K, and Arsenal came from two goals down to draw 2-2 away to Standard Liege and finish first in their pool. The upset of the night came in Group J as Crivelli scored a 90th-minute winner against Borussia Moenchengladbach to send Basaksehir through and knock the Germans out, with AS Roma grabbing the runner-up spot thanks to a 2-2 home draw with Wolfsberger as the Europa League group stage concluded on Thursday.
A round-up of Tuesday's action in the UEFA Champions League.
Pep Guardiola's ManchesterCity will play Romanian side Steaua Bucharest in the Champions League playoff round after the draw was made in Nyon on Friday.
Images from the Champions League matches played across Europe on Wednesday.
Real Madrid's Cristiano Ronaldo was named UEFA's Player of the Year, beating Lionel Messi and Gianluigi Buffon to the prize, European soccer's governing body announced during the Champions League group stage draw in Monaco on Thursday.
New signings Radamel Falcao and Diego scored to give Atletico Madrid a 2-0 win over Celtic as the Europa League group stage kicked off on Thursday.
Here is a quick fact-box on new Real Madrid coach Rafael Benitez, who was appointed to replace Italian Carlo Ancelotti on Wednesday.